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Binding of SARS-CoV-2-S1-RBD to His-tag-labeled ACE2. (a) The KD of RBD and ACE2 in its natural lipid environment is 37 nM. A serial dilution of RBD from 5 μM–0.15 nM was used. Each KD value was calculated from dose–response curves obtained in independent experiments using the stably transfected HEK293 ACE2 His-tag cell line. (b) Representative dose–response curve. (c) MST traces.
