Table 1.
Comparative cytotoxic activity of furyl and N-tolyl containing Schiff base and the corresponding aminophosphonate [62].
| Cell Line | IC50 Value (µM) a | |||||
|---|---|---|---|---|---|---|
| Cisplatin | 2 | 3 | 4 | 5 | 6 | |
| LAMA-84 b | 18.2 ± 1.7 | 39.9 ± 2.1 | 251.9 ± 7.3 | >400.0 | 71.2 ± 2.4 | 119.4 ± 6.3 |
| K-562 b | 25.7 ± 2.1 | 29.9 ± 1.9 | 212.9 ± 12.1 | 352.9 ± 11.7 | 22.9 ± 0.9 | 42.4 ± 3.0 |
| HL-60 b | 7.8 ± 1.1 | >400.0 | >400.0 | 163.4 ± 5.3 | 74.8 ± 2.7 | >400.0 |
| HL-60/DOX c,d | 14.5 ± 1.4 | 68.6 ± 4.0 | 226.1 ± 5.9 | 190.0 ± 4.7 | 115.2 ± 7.1 | 107.2 ± 4.1 |
a Arithmetic mean_standard deviation of at least 6 independent experiments. b Chronic myeloid leukemia. c Acute promyelocyte leukemia. d Multi-drug-resistant (mdr) phenotype due to overexpression of MRP-1 (ABCC1) transporter.