Table 4.

Proliferative activity and clastogenic effect of ICR mice bone marrow cells after i.p. application of the bis-aminophosphonates 3 and 4 [78].

Bis- Aminophosphonates and Doses	Time after Treatment	Number of Metaphases Scored	Type of Chromosome Aberrations					Mitotic Index (‰) (X ± m)	Percentage of Cells with Aberrations (X ± m)
			Breaks	Fragments	Rearrangements
					c/c	t/t	c/t
(3) 10 mg/kg	24 h	400	0	3	17	0	0	12.07 ± 0.99	5.00 ± 0.84
	48 h	450	4	5	11	0	0	11.18 ± 0.68	4.37 ± 0.59
(3) 100 mg/kg	24 h	400	10	13	13	3	0	8.20 ± 0.72	9.75 ± 0.88
	48 h	400	9	7	8	1	0	7.27 ± 0.83	6.25 ± 0.70
(4) 10 mg/kg	24 h	400	5	5	10	2	0	8.39 ± 0.35	5.50 ± 0.33
	48 h	400	3	8	6	1	0	8.93 ± 0.51	4.50 ± 0.33
(4) 100 mg/kg	24 h	400	21	8	17	0	0	10.08 ± 0.73	11.50 ± 0.50
	48 h	400	8	8	13	0	0	7.90 ± 0.34	7.25 ± 0.53
Mit. C 3.5 mg/kg	24 h	200	17	30	7	1	0	5.49 ± 0.19	30.50 ± 2.36
	48 h	400	17	24	20	0	0	7.29 ± 0.34	15.80 ± 0.81
DMSO	24 h	500	1	1	4	0	0	15.14 ± 0.46	1.40 ± 0.30
	48 h	500	2	0	2	0	0	12.47 ± 1.07	0.80 ± 0.32
Control 0.9% NaCl	24 h	700	4	0	4	0	0	20.06 ± 1.38	1.14 ± 0.34
	48 h	500	0	0	3	0	0	16.88 ± 0.56	0.60 ± 0.30