Table 2.
The physiochemical and ADMET properties of the conjugates.
| Conjugate | MW | HBD | HBA | QPlogPo/w | QPlogHERG | QPPCaco | QPlogBB | QPlogKhsa |
|---|---|---|---|---|---|---|---|---|
| 4 | 360.47 | 3 | 7 | 2.617 | −5.908 | 237.115 | −1.649 | 0.114 |
| 6 | 443.57 | 2 | 8 | 4.011 | −6.829 | 568.346 | −1.265 | 0.346 |
| 8 | 452.57 | 2 | 9 | 4.13 | −7.227 | 510.708 | −1.536 | 0.468 |
| 11 | 402.50 | 2 | 7 | 3.263 | −6.067 | 196.034 | −1.805 | 0.379 |
| 15 | 476.52 | 2 | 9 | 4.263 | −8.303 | 445.399 | −1.467 | 0.42 |
| 16 | 490.55 | 2 | 9 | 4.631 | −8.203 | 522.792 | −1.416 | 0.573 |
| 17 | 479.52 | 2 | 8 | 4.395 | −7.972 | 342.919 | −1.644 | 0.563 |
| 18 | 440.48 | 2 | 7 | 3.777 | −7.161 | 203.357 | −1.715 | 0.483 |