Table 2.
Changes in parameters for glycemic control, insulin resistance, and insulin secretion by week.
| Week 0 | Week 24 | Week 52 | Mean Change at Week 52 | p-Value between Groups at Week 52 | ||
|---|---|---|---|---|---|---|
| HbA1c (%) | PEMA (n = 141) | 6.92 ± 0.78 | 7.03 ± 0.93 | 6.99 ± 0.81 | 0.06(−0.04 to 0.16) | 0.940 |
| CTRL (n = 138) | 6.83 ± 0.59 | 6.94 ± 0.76 | 6.89 ± 0.80 | 0.06(−0.05 to 0.18) | ||
| HOMA2-R | PEMA (n = 141) | 2.11 (1.53, 2.95) | a 2.01 (1.43, 2.77) | 1.92 (1.45, 2.66) * | −0.20(−0.33 to −0.20) | 0.017 |
| CTRL (n = 138) | 1.99 (1.47, 2.82) | b 1.98 (1.51, 2.74) | 1.94 (1.47, 2.87) | 0.03(−0.08 to 0.11) | ||
| HOMA2-β | PEMA (n = 141) | 75.0 (57.2, 95.3) | a 69.0 (52.0, 84.8) | 69.4 (55.5, 91.7) | −3.9(−5.6 to −1.0) | 0.451 |
| CTRL (n = 138) | 75.9 (59.1, 94.0) | b 78.0 (55.9, 100.1) | 71.3 (54.4, 93.0) | −1.1(−3.0 to 1.5) | ||
| Disposition index | PEMA (n = 141) | 0.36 (0.28, 0.46) | a 0.35 (0.26, 0.47) | 0.36 (0.27, 0.53) | 0.02(−0.01 to 0.04) | 0.030 |
| CTRL (n = 138) | 0.37 (0.27, 0.48) | b 0.36 (0.30, 0.47) | 0.36 (0.27, 0.47) | −0.01(−0.04 to 0.01) |
Data are shown as mean ± SD, median (25% percentile, 75% percentile), or mean or median change (95% confidence interval). * p < 0.05 versus Week 0, paired t-test. a Data were obtained in 132 patients. b Data were obtained in 133 patients. PEMA, pemafibrate; CTRL, control; HbA1c, glycated hemoglobin; HOMA, homeostatic model assessment.