Table 5.

Characteristics of the cohort members by clusters

	Cluster 1	Cluster 2	Cluster 3	P-value
	(N = 1,237)	(N = 662)	(N = 294)
Male gender	799 (64.6%)	443 (66.9%)	207 (70.4%)	0.143
Age class (years at index date)
18 - 29	632 (51.1%)	351 (53.0%)	221 (75.2%)	< 0.001
30 - 40	605 (48.9%)	311 (47.0%)	73 (24.8%)
Number of co-treatments:
0	866 (70.0%)	407 (61.5%)	173 (58.8%)	<0.001
1-2	351 (28.4%)	247 (37.3%)	121 (41.2%)
$\ge 3$	20 (1.6%)	8 (1.2%)	0 (0.0%)
Clinical statusa
Good	636 (51.4%)	324 (48.9%)	105 (35.7%)	<0.001
Intermediate	121 (9.8%)	57 (8.6%)	14 (4.8%)
Poor	480 (38.8%)	281 (42.5%)	175 (59.5%)
Weekly variety of treatments b: mean (SD)
No treatments	39.6 (12.2)	5.0 (5.9)	1.9 (3.0)	<0.001
Low	9.0 (9.6)	23.0 (13.7)	7.5 (6.5)
Medium	2.9 (5.0)	22.8 (13.9)	17.9 (8.8)
High	0.5 (2.2)	1.2 (2.9)	24.7 (12.2)

^aClinical status was assessed by the MCS, and 3 categories were considered: good (score=0), medium (score 1 - 4), poor (score$\ge 5$);

^bTreatments are considered during the first year of follow-up