TABLE 3.
Summary of challenge outcome
| Animals | No. of animals protected/total no. (%)
|
Pa | |
|---|---|---|---|
| E11S clone | Uncloned SIVmne | ||
| Immunized | |||
| Protected | 14/16 (88) | 3/10 (30) | 0.009 |
| Transiently virus positive | 2/16 (12) | 3/10 (30) | 0.03 |
| Persistently virus positive | 0/16 (0) | 4/10 (40) | 0.01 |
| Controls | |||
| Uninfected | 1/15 (7) | 0/10 (0) | 1.0 |
| Persistently virus positive | 14/15 (93) | 10/10 (100) | 1.0 |
| P | <0.001b | 0.005c | |
a
P values in this column are based on comparisons between the outcomes of challenge with E11S clone and uncloned SIVmne.
b
P value for the difference between the number of animals in the immunized group protected against E11S and that in the control group (14 of 16 and 1 of 15, respectively).
c
P value for the difference between the number of animals in the immunized group showing protection or transient viremia after uncloned SIVmne challenge and that in the control group (6 of 10 and 0 of 10, respectively).