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. 2023 Jul 25;16:4817–4834. doi: 10.2147/IDR.S419629

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© 2023 Gómez-Gaviria et al.

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Phagocytosis and receptors involved in the immune recognition of different species of the Sporothrix pathogenic clade. Macrophages and dendritic cells can phagocytose yeast-like cells and conidia of S. schenckii, S. brasiliensis, and S. globosa. S. globosa is the species most phagocytosed by both types of cells, followed by S. brasiliensis and, finally, S. schenckii. The receptors involved in such recognition vary between species and morphologies. S. globosa is recognized by dectin-1 and TLR2 receptors, while S. brasiliensis and S. schenckii are recognized by dectin-1, TLR2, TLR4, CR3, DC-SIGN, and MR.