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Reagents and conditions: synthesis of 19-S2: pyrimethamine, HNO3, H2SO4, 0°C to 50°C, 80 minutes, 99% yield. Synthesis of 19-S, 19-S1, 19-S3 through 19-S9, and 19-S11 through 19-S14: 19-S2, amine (neat), 150°C, sealed tube, 6 hours, 22–86% yield. Synthesis of 19-S10: 19-S9, TFA, CH2Cl2, room temperature, 80% yield. TFA, trifluoroacetic acid.
