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Protective efficacy of oriented HA constructs. a) Weight loss of mice immunized with either VLP-HARegular, VLP-HAInverted, or VLP and subsequently infected with cH6/1N5 virus at four different doses (101, 102, 103, or 104 pfu/mouse; mean ± SEM; n=3). b) Survival of mice immunized with either VLP-HARegular, VLP-HAInverted, or VLP and subsequently infected with cH6/1N5 virus at four different doses (101, 102, 103, or 104 pfu/mouse; n=3).
