Table 3.

Overview of the geometric mean C_trough and 95% CI of the GM per drug

Drug	Wildtype CYP3A4		CYP3A4*22 carriers
	GM Ctrough	95% CI GM	GM Ctrough	95% CI GM
Cabozantinib	1063 ng/mL	728–1550	1,117 ng/mL	796–1568
Dabrafenib	120 ng/mL	74–195	101 ng/mL	39–262
Imatinib	1200 ng/mL	1072–1345	792 ng/mL	636–985
Osimertinib	219 ng/mL	177–270	235 ng/mL	72–766
Pazopanib	27 mg/L	22–34	28 mg/L	21–39
Sunitinib	61 ng/mL	51–73	66 ng/mL	40–107

CI confidence interval, GM geometric mean