Table 2.
Cox proportional hazard regression model assessing predictors of first/further decompensation or liver-related death
| Overall cohort (n = 249) |
First/further decompensation or liver-related mortality during follow-up | |||||
|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | |||||
| Patient characteristics | HR | 95%CI | p value | HR | 95%CI | p value |
| Age (per year) | 1.00 | 0.98–1.02 | 0.876 | |||
| MELD (per point) | 1.10 | 1.04–1.17 | < 0.001 | 1.05 | 0.97–1.13 | 0.235 |
| HVPG (per mmHg) | 1.09 | 1.05–1.14 | < 0.001 | 1.08 | 1.03–1.12 | < 0.001 |
| MAP (per mmHg) | 0.97 | 0.95–0.98 | < 0.001 | 0.97 | 0.96–0.99 | 0.001 |
| IL-6 (per pg/mL) | 1.02 | 1.01–1.02 | 0.002 | 1.03 | 1.01–1.04 | < 0.001 |
| LPS (per EU/mL) | 0.75 | 0.47–1.18 | 0.212 | |||
| LTA (per 10 pg/mL) | 1.01 | 0.99–1.02 | 0.138 | |||
| BactDNA + (≥ 5 pg /mL) | 1.31 | 0.81–2.14 | 0.275 | |||
| TNF-α (per pg/mL) | 0.99 | 0.97–1.01 | 0.259 | |||
| IL-10 (per pg/mL) | 0.99 | 0.94–1.04 | 0.625 | |||
p-values < 0.05 are indicated in bold
bactDNA bacterial DNA, HVPG hepatic venous pressure gradient, IL-6/-10 interleukin-6/-10, MAP mean arterial pressure, MELD Model of End Stage Liver Disease, TNF-α tumor necrosis factor-alpha