Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jul 29;14:4566. doi: 10.1038/s41467-023-40173-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — A Uniform manifold approximation and projection (UMAP) visualization of seed cells representing 48 lung cell types of normal human lung, termed LungMAP Human Lung CellRef Seed. Cells were colored by their predicted seed identities. B UMAP visualization of the complete single-cell reference for normal human lung, denoted as LungMAP Human Lung CellRef, which contains 347,970 cells from 104 donors and defines 48 cell types in normal human lung. Cells were colored by their predicted identities. C Validation of the seed cell identity using the expression of cell type selective marker genes derived from LungMAP CellCards. D Reconstruction of cell lineage relationships using hierarchical clustering analysis of cell type pseudo-bulk gene expression profiles. Color represents Pearson’s correlation value of pseudo-bulk expression profiles. Labels ending with “.Seed” represent pseudo-bulk profiles created by averaging gene expression in the cells of each cell type in the human lung CellRef Seed, while labels ending with “.CellRef” represent pseudo-bulk profiles created using gene expression of each cell type in the complete human lung CellRef.