TABLE II.

Prediction Performances of Prediction Methods in Discovery Dataset

Model	Added Covariate	A+B+Imaging	A+Imaging	Imaging only
CPM	M1. SC(+) + Covariate	0.46 (2.0e-6)	0.46 (1.6e-6)	0.32 (1.3e-3)
	M2. SC(-) + Covariate	0.50 (2.1e-7)	0.44 (7.0e-6)	0.28 (5.2e-3)
	M3. SC(+, -) + Covariate	0.56 (2.7e-9)	0.53 (2.9e-8)	0.40 (4.7e-5)
	M4. FC(+) + Covariate	0.59 (3.5e-10)	0.58 (6.5e-10)	0.35 (4.8e-4)
	M5. FC(-) + Covariate	0.52 (4.6e-8)	0.51 (1.3e-7)	0.45 (3.5e-6)
	M6. FC(+, -) + Covariate	0.59 (2.3e-10)	0.59 (3.9e-10)	0.54 (1.6e-8)
	M7. SC(+) + FC(+) + Covariate	0.46 (2.0e-6)	0.37 (1.9e-4)	0.24 (1.8e-2)
	M8. SC(-) + FC(-) + Covariate	0.58 (4.0e-10)	0.58 (7.4e-10)	0.50 (2.1e-7)
	M9. SC(+,-) + FC(+,-) + Covariate	0.61 (2.8e-11)	0.55 (6.5e-9)	0.53 (1.9e-8)
SVR	M3. SC(+, -) + Covariate	0.46 (1.2e-6)	0.41 (2.3e-5)	0.30 (1.8e-3)
	M6. FC(+, -) + Covariate	0.48 (4.7e-7)	0.47 (5.0e-7)	0.43 (7.5e-6)
	M9. SC(+,-) + FC(+,-) + Covariate	0.57 (4.2e-10)	0.51 (4.0e-8)	0.47 (5.9e-7)
Elastic net	M3. SC(+, -) + Covariate	0.47 (9.7e-4)	0.44 (6.6e-6)	0.30 (1.9e-3)
	M6. FC(+, -) + Covariate	0.52 (6.5e-8)	0.45 (1.6e-6)	0.39 (4.1e-5)
	M9. SC(+,-) + FC(+,-) + Covariate	0.56 (4.0e-9)	0.38 (NS)	0.32 (8.9e-4)
LASSO	M3. SC(+, -) + Covariate	0.47 (7.8e-7)	0.41 (1.6e-5)	0.31 (1.6e-3)
	M6. FC(+, -) + Covariate	0.50 (1.3e-7)	0.51 (4.1e-8)	0.50 (1.3e-7)
	M9. SC(+,-) +FC(+,-) + Covariate	0.50 (1.3e-7)	0.51 (4.0e-8)	0.50 (1.2e-7)
PLSR	M3. SC(+, -) + Covariate	0.51 (7.2e-8)	0.50 (2.3e-7)	0.37 (2.0e-4)
	M6. FC(+, -) + Covariate	0.58 (6.5e-11)	0.55 (2.7e-11)	0.52 (3.5e-8)
	M9. SC(+,-) + FC(+,-) + Covariate	0.59 (6.4e-11)	0.58 (2.0e-11)	0.53 (2.9e-8)

Correlation between predicted and observed scores (corresponding p-value). Bolded values correspond to the highest correlation in their respective models. Values in red correspond to the highest correlation when added the same covariate among five models. A – Demographic; B – HIV Measure; + = positive; - = negative; SC = structural connectivity; FC = functional connectivity; NS= not significant.