Table 3:
Assessing the performance of MMB-eGFR and of the mean of MMB-eGFR and CKD-EPICys equations (vs mGFR) in the four study populations, compared with those of the CKD-EPICys, CKD-EPICr-Cys2021 and FAScombi equations.
| Mean bias (95% CI) (mL/min/1.73 m2) | SD of the bias (mL/min/1.73 m2) | Accuracy within 20% (95% CI) (%) | Accuracy within 30% (95% CI) (%) | Lin's CCC (95% CI) | |
|---|---|---|---|---|---|
| Development population (n = 117) | |||||
| MMB-eGFR | 0.8 (−1.9 to 3.5) | 14.8 | 85.5 (79.1 to 91.9) | 95.7 (92.1 to 99.4) | 0.69 (0.58 to 0.77) |
| Mean MMB-eGFR/CKD-EPICys | −2.0 (−4.2 to 0.2) | 12.5 | 88.9 (83.2 to 94.6) | 99.1 (97.5 to 100) | 0.73 (0.64 to 0.80) |
| CKD-EPICys | −5.0 (−8.0 to −2.0) | 16.6 | 78.6 (71.2 to 86.1) | 91.5 (86.4 to 96.5) | 0.56 (0.43 to 0.67) |
| CKD-EPICr-Cys2021 | 2.5 (0.0 to 5.1) | 14.2† | 80.3 (73.1 to 87.5) | 94.9 (90.9 to 98.9) | 0.64 (0.53 to 0.73) |
| FAScombi | −4.5 (−7.2 to −1.7) | 15.0† | 83.8 (77.1 to 90.4) | 94.0 (89.7 to 98.3)† | 0.58 (0.45 to 0.69) |
| Validation population 1 (n = 110) | |||||
| MMB-eGFR | −1.1 (−3.7 to 1.5) | 14.4 | 83.6 (76.7 to 90.6) | 96.4 (92.9 to 99.9) | 0.56 (0.42 to 0.67) |
| Mean MMB-eGFR/CKD-EPICys | 3.0 (1.1 to 4.9) | 10.2 | 90.0 (84.4 to 99.6) | 99.1 (97.3 to 100) | 0.69 (0.58 to 0.77) |
| CKD-EPICys | 7.1 (4.7 to 9.4) | 12.7 | 76.4 (68.4 to 84.3) | 92.7 (87.9 to 97.6) | 0.54 (0.41 to 0.64) |
| CKD-EPICr-Cys2021 | 10.6 (8.5 to 12.6) | 11.1* | 72.7 (64.4 to 81.1)† | 90.9 (85.5 to 96.3)† | 0.51 (0.39 to 0.61) |
| FAScombi | 4.5 (1.8 to 7.2) | 14.5† | 81.8 (74.6 to 89.0) | 92.7 (87.9 to 97.6)† | 0.57 (0.43 to 0.67) |
| Validation population 2 (n = 54) | |||||
| MMB-eGFR | −2.3 (−5.8 to 1.2) | 13.2 | 64.8 (52.1 to 77.6) | 79.6 (68.9 to 90.4) | 0.89 (0.83 to 0.93) |
| Mean MMB-eGFR/CKD-EPICys | −5.9 (−8.7 to −3.1) | 10.4 | 64.8 (52.1 to 77.6) | 94.4 (88.3 to 100) | 0.92 (0.87 to 0.95) |
| CKD-EPICys | −9.5 (−13.0 to −6.0) | 13.2 | 46.3 (33.0 to 59.6) | 75.9 (64.5 to 87.3) | 0.86 (0.78 to 0.92) |
| CKD-EPICr-Cys2021 | −4.1 (−7.1 to −1.1) | 11.4 | 66.7 (54.1 to 79.2) | 87.0 (78.1 to 96.0) | 0.92 (0.87 to 0.95) |
| FAScombi | −5.2 (−8.6 to −1.8) | 12.7† | 63.0 (50.1 to 75.8) | 83.3 (73.4 to 93.3)† | 0.88 (0.80 to 0.93) |
| Validation population 3 (n = 60) | |||||
| MMB-eGFR | 7.4 (3.2 to 11.5) | 16.3 | 56.7 (44.1 to 69.2) | 75.0 (64.0 to 86.0) | 0.72 (0.58 to 0.82) |
| Mean MMB-eGFR/CKD-EPICys | 3.2 (0.1 to 6.2) | 12.1 | 71.7 (60.3 to 83.1) | 86.7 (78.1 to 95.3) | 0.87 (0.81 to 0.92) |
| CKD-EPICys | −1.0 (−6.2 to 4.2) | 20.5 | 40.0 (27.6 to 52.4) | 61.7 (49.4 to 74.0) | 0.75 (0.65 to 0.82) |
| CKD-EPICr-Cys2021 | 3.8 (0.4 to 7.1) | 13.3 | 56.7 (44.1 to 69.2)† | 81.7 (71.9 to 91.5) | 0.85 (0.78 to 0.90) |
| FAScombi | 3.3 (0.5 to 6.2) | 11.3* | 66.7 (54.7 to 78.6) | 78.3 (67.9 to 88.8) | 0.87 (0.79 to 0.92) |
P-values were calculated between each eGFR equation based on age and sex (CKD-EPICys, CKD-EPICr-Cys2021 and FAScombi) and MMB-eGFR, in each population. *P < .05. For CKD-EPICr-Cys2021 and FAScombi, P-values were also calculated against Mean MMB-eGFR/CKD-EPICys in each population. †P < .05. The precision (SD of the bias) comparison was performed with Pitman's test. Accuracy comparison was performed with McNemar's test.
Lin's CCC, Lin's concordance correlation coefficient.