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. 2023 Jul 31;8:282. doi: 10.1038/s41392-023-01501-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — The mechanisms of mechanical cues-induced cancer cell behavior in tumor microenvironment. Mechanical cues induced cancer cell growth, invasion, migration and metastasis in multiple signaling pathways. Cancer-associated fibroblasts engage in ECM remodeling process, which trigger cancer cell migration and dissemination. ECF extracellular fluid, ECM extracellular matrix, EMT epithelial-to-mesenchymal transition, HDAC6 histone deacetylase 6, NHE1 Na+/H+ exchanger 1, TRPV4 transient receptor potential vanilloid 4. This figure was created using Biorender.com