TABLE 3.
Associations between plasma‐derived neurodegeneration biomarkers and neuropsychiatric symptoms.
| t‐tau | NfL | |||
|---|---|---|---|---|
| NPS (Outcome) | OR [95% CI] | p | OR [95% CI] | p |
| Agitation | 0.71 [0.46, 1.10] | 0.128 | 0.91 [0.52, 1.61] | 0.753 |
| Anxiety | 0.87 [0.63, 1.20] | 0.404 | 0.70 [0.41, 1.20] | 0.193 |
| Apathy/indifference | 0.99 [0.71, 1.36] | 0.936 | 0.88 [0.57, 1.37] | 0.580 |
| Appetite/eating change | 1.44 [1.08, 1.92] | 0.012 | 1.25 [0.98, 1.59] | 0.069 |
| Nighttime behavior | 1.21 [0.89, 1.64] | 0.217 | 0.75 [0.45, 1.25] | 0.270 |
| Depression/dysphoria | 1.12 [0.90, 1.39] | 0.308 | 1.13 [0.90, 1.41] | 0.284 |
| Disinhibition | 1.34 [0.90, 2.00] | 0.149 | 0.94 [0.53, 1.66] | 0.822 |
| Irritability/lability | 0.84 [0.64, 1.11] | 0.225 | 0.99 [0.70, 1.40] | 0.949 |
| BDI‐II ≥13 | 1.18 [0.93, 1.50] | 0.183 | 1.07 [0.83, 1.37] | 0.611 |
| BAI ≥10 | 0.97 [0.75, 1.24] | 0.792 | 0.97 [0.70, 1.32] | 0.824 |
| β [95% CI] | p | β [95% CI] | p | |
|---|---|---|---|---|
| NPI‐Q severity score | 0.04 [−0.07, 0.16] | 0.443 | 0.01 [−0.12, 0.14] | 0.890 |
| BDI‐II total score | 0.17 [−0.14, 0.48] | 0.278 | 0.11 [−0.24, 0.46] | 0.531 |
| BAI total score | 0.23 [−0.07, 0.53] | 0.135 | 0.16 [−0.17, 0.49] | 0.343 |
Abbreviations: 95% CI, 95% confidence interval; BAI, Beck Anxiety Inventory; BDI‐II, Beck Depression Inventory II; NfL, neurofilament light; NPI‐Q, Neuropsychiatric Inventory Questionnaire; NPS, neuropsychiatric symptom; OR, odds ratio; t‐tau, total tau; β, regression coefficient.
For all non‐reported NPI‐Q‐assessed NPS (i.e., delusions, euphoria/elation, hallucinations, motor behavior), there were not enough events to be included in the logistic regression models. Significant p‐values appear bold; p < 0.05, indicates statistical significance.