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. 2023 Jul 11;26(8):107333. doi: 10.1016/j.isci.2023.107333

Figure 5.

Figure 5

PAK1 inhibitors attenuate the ischemic insults in mice

(A) Representative TTC-stained coronal sections.

(B) Quantification of infarct volume showing that PAK1 inhibitors protect against brain damage induced by MCAO/R 24h. Data are expressed as mean ± SEM (n = 6–7). ∗∗p < 0.01, ∗∗∗p < 0.001 versus vehicle group, one-way ANOVA with Dunnet’s post hoc test.

(C) Statistic analysis of brain edema in ischemic hemisphere. Data are expressed as mean ± SEM (n = 6–7). ∗p < 0.05, ∗∗∗p < 0.001 versus vehicle group, one-way ANOVA with Dunnet’s post hoc test.

(D) PAK1 inhibitors exert behavior relief as measured by Zea Longa score. Data are expressed as mean ± SEM (n = 9–10). ∗p < 0.05 versus vehicle group, Kruskal-Wallis test with Dunn’s post hoc test.