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. 2023 Jul 28;9(3):e003148. doi: 10.1136/rmdopen-2023-003148

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Spontaneous secretion of ATA-IgG by PBMC in relation to the presence and severity of ILD. PBMC from ATA+SSc patients with ILD (n=14) or without ILD (n=7) were cultured without stimulation. ATA-IgG was measured in culture supernatants by ELISA after 7 days. (A) Levels of ATA-IgG (median in aU/mL) were compared between groups. (B) Levels of ATA-IgG produced spontaneously (median in aU/mL) in relation to the lung fibrosis score. (C) Percentage of wells positive for ATA-IgG were compared between groups. (D) ATA-IgG plasma levels in the same patients. Lines depict median values. Dotted line represents the cut-off based on the mean plus two times the SD of measurements of HC (n=11) and patients with RA (n=3). P values and Spearman correlation (ρ) are shown. ATA, anti-topoisomerase antibodies; HC, healthy controls; IgG, immunoglobulin G; ILD, interstitial lung disease; PBMC, peripheral blood mononuclear cells; SSc, systemic sclerosis.