Table 1.

Healthcare resource utilization categories.

Categories	Subcategories	Relevant NTD items
Direct medical	Inpatient care	Hospital visits, rehab visits
	Day admissions	Hospital visits, rehab visits
	Consultations	Occupational/speech/physio/psycho/acupuncture therapy/neurologist
	Tests	Cerebral MRI, spinal MRI, blood samples
	Medications	Wide range of medications, which are not DMTs including fampridine, cannabidiol/delta-9-tetrahydrocannabinol spray
	DMTs	DMTs
Direct non-medical	Investments	Wheelchair, walker, stairlift, house modification, crutches, incontinence pads, diapers, bed pads, tub lift
	Community services	Community care, care during day, domestic support
	Informal care	Care by family
Indirect	Short-term absence	Sick days
	Long-term absence, invalidity, early retirement	Disability pensions, other payouts for extended periods including “Uebergangsgeld” (interim pay) and “Krankengeld” (sick pay)

We aligned our HCRU categories with those applied in Flachenecker et al. ¹⁰

DMT, disease-modifying therapy; HCRU, healthcare resource utilization; MRI, magnetic resonance imaging; NTD, NeuroTransData.