Table 4. Treatment for microvascular obstruction.

Disease	Compound	Effect	Ref.
AMI: acute myocardial infarction; CBF: coronary blood flow; MVO, microvascular obstruction; PCI: percutaneous coronary intervention; STEMI: ST-elevation myocardial infarction.
STEMI + PCI	Prasugrel/ticagrel + aspirin or clopidogrel + aspirin	Prasugrel/ticagrelor were associated with smaller infarct size and lower MVO incidence versus clopidogrel	[116]
STEMI + PCI	Tirofiban + aspirin and clopidogrel	Reduction in the incidence of MVO	[28]
STEMI + PCI	Adenosine	Had no effect on the incidence of MVO	[106–117]
AMI + PCI	Nicorandil	Reduction the incidence of MVO by 50%	[109]
AMI + PCI	Nicorandil + adenosine	Reduction the incidence of no-reflow by 40%	[119]
STEMI + PCI	Nicorandil	Reduction the incidence of MVO	[120]
AMI + PCI	Epinephrine	Significant improvement CBF	[123]
AMI + PCI	Verapamil	Reduction the MVO area	[99]
AMI + PCI	Nicardipine	Reduction no-reflow in 71 of 72 patients	[124]
AMI + PCI	Nicardipine + adenosine + nitroglycerine	Reversion no-reflow	[125]