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. 2023 Jul 17;14:1231259. doi: 10.3389/fphys.2023.1231259

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Copyright © 2023 Keidar, Peretz and Yaniv.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model prediction of metabolic homeostasis is response to electrical stimulus. (A) Mitochondrial Ca²⁺, (B) FADH₂ concentration, (C) NADH concentration and (D) oxygen consumption in response to electrical stimulus frequency that was raised from 0.25 Hz to 2 Hz and then returned to 0.25 Hz. The model was tested without Ca²⁺ push and pull mechanisms, with only Ca²⁺ push mechanism and with both Ca²⁺ push and pull mechanisms.