Supplementary Table 2.

Potential T2D causing genes that are highly represented in five shared pathways among the top 10 affected pathways of four datasets using top-down approach.

						Spliceosome	ErbB signaling pathway	SNARE interactions in vesicular transport	TGF-beta signaling pathway	Focal adhesion
Gene	Total Frequency	T2D1	T2D2	T2D3	T2DC	hsa03040	hsa04012	hsa04130	hsa04350	hsa04510
AKT1	8	2	2	2	2		✓			✓
AKT2	8	2	2	2	2		✓			✓
AKT3	8	2	2	2	2		✓			✓
BRAF	8	2	2	2	2		✓			✓
CRK	8	2	2	2	2		✓			✓
CRKL	8	2	2	2	2		✓			✓
EGF	8	2	2	2	2		✓			✓
EGFR	8	2	2	2	2		✓			✓
ERBB2	8	2	2	2	2		✓			✓
GRB2	8	2	2	2	2		✓			✓
GSK3B	8	2	2	2	2		✓			✓
HRAS	8	2	2	2	2		✓			✓
JUN	8	2	2	2	2		✓			✓
MAP2K1	8	2	2	2	2		✓			✓
MAPK1	12	3	3	3	3		✓		✓	✓
MAPK10	8	2	2	2	2		✓			✓
MAPK3	12	3	3	3	3		✓		✓	✓
MAPK8	8	2	2	2	2		✓			✓
MAPK9	8	2	2	2	2		✓			✓
MYC	8	2	2	2	2		✓		✓
PAK1	7	2	2	1	2		✓			✓
PAK2	7	2	2	2	1		✓			✓
PAK7	7	2	2	1	2		✓			✓
PIK3CA	8	2	2	2	2		✓			✓
PIK3CB	8	2	2	2	2		✓			✓
PIK3CD	8	2	2	2	2		✓			✓
PIK3CG	7	2	2	2	1		✓			✓
PIK3R1	8	2	2	2	2		✓			✓
PIK3R2	8	2	2	2	2		✓			✓
PIK3R3	8	2	2	2	2		✓			✓
PIK3R5	7	2	2	1	2		✓			✓
PRKCA	8	2	2	2	2		✓			✓
PRKCB	8	2	2	2	2		✓			✓
PRKCG	7	2	1	2	2		✓			✓
PTK2	8	2	2	2	2		✓			✓
RAF1	8	2	2	2	2		✓			✓
RHOA	6	2	1	2	1		✓		✓	✓
RPS6KB1	8	2	2	2	2		✓		✓
SHC1	8	2	2	2	2		✓			✓
SHC3	8	2	2	2	2		✓			✓
SOS1	8	2	2	2	2		✓			✓
SOS2	6	0	2	2	2		✓			✓
SRC	8	2	2	2	2		✓			✓
THBS1	8	2	2	2	2				✓	✓