Supplementary Table 7.

Potential T2D causing genes that are highly represented in the gold-standard pathways of T2D in our analy in our analysis.

	Frequencies in the gold-standard pathways of T2D, obtained using different datasets					Glycolysis / Gluconeogenesis	Fatty acid metabolism	Valine, leucine and isoleucine degradation	Valine, leucine and isoleucine biosynthesis	Biosynthesis of unsaturated fatty acids	PPAR signaling pathway	Calcium signaling pathway	Cell cycle	Wnt signaling pathway	Notch signaling pathway	JAK-STAT signaling pathway
Gene	Total	T2D1	T2D2	T2D3	T2DC	hsa00010	hsa00071	hsa00280	hsa00290	hsa01040	hsa03320	hsa04020	hsa04110	hsa04310	hsa04330	hsa04630
ACAA1	14	4	2	4	4		✓	✓			✓
ACADM	11	3	2	3	3		✓	✓			✓
ACOX1	12	3	3	3	3		✓				✓
ACSL1	12	3	3	3	3		✓				✓
ACSL3	12	3	3	3	3		✓				✓
ACSL5	11	3	3	3	2		✓				✓
AKT2	12	3	3	3	3											✓
AKT3	12	3	3	3	3											✓
ALDH1B1	12	3	3	3	3	✓	✓	✓
ALDH2	12	3	3	3	3	✓	✓	✓
ALDH3A2	12	3	3	3	3	✓	✓	✓
ALDH7A1	12	3	3	3	3	✓	✓	✓
ALDH9A1	12	3	3	3	3	✓	✓	✓
CPT1A	12	3	3	3	3		✓				✓
CPT1B	12	3	3	3	3		✓				✓
CREBBP	15	4	4	3	4								✓	✓	✓	✓
EHHADH	11	3	2	3	3		✓	✓			✓
EP300	14	4	3	3	4								✓	✓	✓	✓
GCK	12	3	3	3	3	✓
GSK3B	12	3	3	3	3								✓	✓
IKBKB	12	3	3	3	3
IRS1	12	3	3	3	3
IRS2	12	3	3	3	3
MAPK10	15	4	4	3	4									✓
MAPK8	15	4	4	3	4									✓
MAPK9	15	4	4	3	4									✓
MYC	12	3	3	3	3								✓	✓		✓
PIK3CA	12	3	3	3	3											✓
PIK3CB	12	3	3	3	3											✓
PIK3CD	12	3	3	3	3											✓
PIK3R1	12	3	3	3	3											✓
PIK3R2	12	3	3	3	3											✓
PIK3R3	12	3	3	3	3											✓