TABLE 2.

Network Meta-Analysis Results on Weight Loss Outcomes: Medications for Obesity Management vs Placebo

	Percent weight loss from baseline at 1 year	≥5% Weight loss	≥10% Weight loss
	Mean difference (95% CrI)	Odds ratio (95% CrI)
Semaglutide	−13.7 (−12.6 to −15.1)	17.3 (8.9-38.3)	22.4 (13.6-36.2)
Liraglutide	−5.0 (−3.9 to −6.1)	4.3 (2.5 to 6.7)	4.2 (2.6 to 5.7)
Phentermine/topiramate	−9.1 (−7.1 to −11)	8.6 (3.3 to 22.0)	8.8 (4.7 to 18.1)
Bupropion/naltrexone	−4.6 (−3.0 to −6.0)	4.3 (1.7-10.2)	3.6 (2.0-6.8)

CrI = credible interval.