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. Author manuscript; available in PMC: 2023 Jul 31.
Published in final edited form as: Compr Physiol. 2021 Apr 1;11(2):1831–1869. doi: 10.1002/cphy.c200030

Figure 5. Ca2+ signaling networks at myoendothelial projections (MEPs).

Figure 5

Ca2+ influx via TRPV4/TRPV3/TRPA1/TRPC3 channels or Ca2+ release from the ER via IP3Rs at MEPs activates nearby small (SK) and intermediate (IK) conductance Ca2+-activated K+ channels. IK/SK channel activation hyperpolarizes endothelial cells (EC) membrane and results in vasodilation. TRPV/TRPA/TRPC, members of transient receptor potential channel family.