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. 2023 Jan 17;53(3):630–639. doi: 10.55730/1300-0144.5625

Figure 5.

Figure 5

LncRNA PART1 regulated miR-17-5p/SOCS6 to inactivate STAT3 signaling pathway A: SOCS6 mRNA expression in OSCC cells and HOECs were analyzed using RT-qPCR. B: TargetScan provided binding sites between miR-17-5p and SOCS6. C: Luciferase reporter test. D–F: Western blot assays were performed to measure the changes in SOCS6 protein expression. G. SOCS6 mRNA expression in SCC9 and CAL27 cells with PART1 overexpression and additional upregulation of miR-17-5p. H–J: Phosphorylated STAT3 and STAT3 proteins were validated by western blot. *p =< 0.032, **p =< 0.0021, ***p =< 0.0002, and ****p < 0.0001.