Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 19;108(8):2101–2115. doi: 10.3324/haematol.2022.282177

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright© 2023 Ferrata Storti Foundation

This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

PMC Copyright notice

Figure 4. — TIGIT⁺ cells produce more IL-10. (A) Quantitative real-time polymerase chain reaction analysis of IL10 baseline expression of chronic lymphocytic leukemia (CLL) samples divided according to IGHV mutational status and TIGIT surface levels. (B) FACS analysis of IL-10 intracellular staining after 5 h stimulation with phorbol 12-myristate 13-acetate (50 ng/mL) and 1 μM ionomycin in CLL samples divided according to IGHV mutational status and TIGIT surface levels. (C) Representative flow cytometry plots of IL-10 production in unstimulated and stimulated CLL cells. Statistical analyses: Student t test. RE: relative expression; IL-10: interleukin-10: B2M: β2-microglobulin; UM: unmutated: M: mutated; NS: unstimulated; PMA/Iono: stimulated with phorbol 12-myristate 13-acetate/ionomycin.