Figure 4.

Differential expression of all NUP98-translocated pediatric acute myeloid leukemia patients. (A) Schematic of differential expression analyses completed for NUP98-translocated samples. The overlap of differentially expressed genes (DEG) identified in each NUP98 cohort is represented in the Venn diagram. (B) DEG between NUP98-translocated AML groups compared to the reference cohort and normal bone marrow (NBM) were identified. Subsets of dysregulated genes were commonly identified in both NUP98-X and NUP98-NSD1 (upper panel) or were identified as shared between NUP98-X and NUP98-KDM5A (lower panel). (C) Commonly DEG found in all three NUP98-translocated pediatric acute myeloid leukemia (AML) subgroups. (D) Mean expression (Z-score transformed) of HOXA9 and HOXB8 interacting partners in NUP98-X translocated AML. The darker shades of red indicate higher expression in the NUP98-X cohort. CPM: counts per million.