FIG. 1.

Alignment of the human dUTPase (DUTH) sequence with consensus sequences (10) for HIV-1 subtypes A to H and group O. Sixteen positions shown in red are strictly conserved. Other consensus residues (over 50% in HIV-1) are shown in green. A question mark denotes the absence of a consensus residue. Numbering corresponds to that in reference 6. The V3 loop and the locations of the five previously recognized conserved motifs in dUTPases (11) are indicated above the alignment. Four of these five motifs correlate with at least one strictly conserved residue. This is also true for other primate lentivirus lineages (Fig. 2). Asterisks indicated conserved residues Asp 368 and Glu 370.