FIG. 2.
Conserved positions in the pairwise alignment of human dUTPase with various HIV-1, HIV-2, and SIV gp120 sequences. The human dUTPase sequence is used as a template to visualize its relationship with gp120 sequences representative of the diversity of the primate lentiviruses (PLVs). PLV type 1 (PLV-1), HIV-1 and SIVCPZ; PLV-2, HIV-2/SIVSM; PLV-3, SIVAGM; and PLV-5, SIVSYK were used according to the nomenclature of Sharp et al. (15). Sequences for the HIV-1_B, HIV-2_A, and HIV-2_B subtype representatives are consensus sequences from the Los Alamos HIV database (10); the GenBank accession numbers for SIVSM, SIVCPZ, SIVAGM, and SIVSYK are X14307, X52154, M66437, and L06042, respectively. Conserved positions are shown in red.