Table 1. Cytotoxicity of the TAML Complexes on Breast cancer Cellsc.
| EC50 (μM) | AuTAML | CuTAML | TAML | tamoxifen | cisplatin |
|---|---|---|---|---|---|
| MCF-7 (ER+) | 7.5 ± 2.4** | 3.1 ± 0.9** | 8.0 ± 2.2** | 8.0 ± 0.7a | 20.7 ± 1.1b |
| MDA-MB 231 (ER–) | 23.5 ± 3.1* | 6.0 ± 1.1** | 21.0 ± 3.5* | 15.2 ± 2.3a | 63.1 ± 1.2b |
a
From ref (65).
b
From ref (66).
c
EC50 values of cytotoxicity of the new compounds after 48 h incubation with respect to the parent molecule tamoxifen and cisplatin in ER+ (MCF-7) and ER– (MDA-MB 231) human breast cancer cells. Mean ± SD of 3 experiments is reported (*p < 0.05; **p < 0.01 compared to negative control).