Table 2.
Serum biomarker cut-off values and probabilities of suicidal behaviour during 12-month follow-up (N = 884)
| Increased suicidal severitya | Fatal/non-fatal suicide attempt | |||||||
|---|---|---|---|---|---|---|---|---|
| Optimal cut-off | OR (95% CI) | Sensitivity (%) | Specificity (%) | Optimal cut-off | OR (95% CI) | Sensitivity (%) | Specificity (%) | |
| Cortisol | >11.7 μg/dL | 1.49 (1.03–2.14)* | 51.0 | 60.4 | >12.0 μg/dL | 7.56 (3.17–18.05)‡ | 84.2 | 63.5 |
| Tumor necrosis factor-α | >0.57 pg/mL | 1.38 (0.95–2.01) | 61.9 | 47.5 | – | |||
| Interleukin-1β | >0.99 pg/mL | 2.73 (1.75–4.26)‡ | 83.2 | 39.8 | – | |||
| Interleukin-10 | >9.53 pg/mL | 1.50 (0.99–2.14) | 64.5 | 44.3 | – | – | – | – |
| Total cholesterol | <155.0 mg/dL | 2.12 (1.45–3.11)‡ | 75.2 | 43.2 | <154.0 mg/dL | 3.61 (1.74–7.46)‡ | 74.6 | 57.9 |
| Folate | <6.05 ng/mL | 1.49 (1.01–2.18)* | 67.5 | 57.9 | <5.95 ng/mL | 2.67 (1.23–5.80)‡ | 80.1 | 74.4 |
| Homocysteine | >11.1 μmol/L | 1.60 (1.09–2.34)† | 60.6 | 53.4 | – | |||
| Brain derived neurotrophic factor | <22.8 ng/mL | 1.40 (0.97–2.01) | 52.7 | 58.1 | ||||
aIncrease in Brief Psychiatric Rating Scale suicidality item score during the follow-up compared to the baseline.
Optimal cut-off values were obtained from the receiver operating characteristic curve.
Odds ratios (95% confidence intervals) [OR (95% CI)] were estimated by using logistic regression analyses after adjustment for age, gender, living alone, religious affiliation, monthly income, atypical feature, number of depressive episodes, number of physical disorders, smoking status, scores on Hospital Anxiety & Depression Scale-anxiety subscale and Alcohol Use Disorders Identification Test, and treatment step.
‡p < 0.001; †p < 0.01; *p < 0.05.
Bold style indicates statistical significance (p < 0.05) after applying the Bonferroni correction.