Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jul 31;15:59. doi: 10.1186/s13073-023-01211-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — Association of immune-cell fractions with smoking, BMI, exercise, and stress. a Heatmap of associations between blood cell-type fractions and smoking in each of 10 cohorts with smoking status information. Cohort sizes are shown above heatmap. Red (blue) tones indicate fractions that increase in smokers (never-smokers). P-values derived from a multivariate regression that included age, sex, and BMI (whenever available) and study-specific confounders as described in “Methods.” Meta(Stouffer) indicates directional Stouffer z-statistic and significance. Associations marked with a * are significant after Bonferroni correction at 0.05 level (i.e., P < 0.05/11). b Barplot displaying the effect size estimates and 95% confidence intervals from a fixed effect inverse variance meta-analysis model. Color bar to the right labels the I² values of heteroscedasticity. c Scatterplot of z-statistics from the directional Stouffer method, against the corresponding statistics from the fixed effect meta-analysis model. R-value of agreement is shown. Gray dashed lines indicate the line P = 0.05. d Heatmap of multivariate associations of immune-cell fractions with epidemiological factors in the TD7k cohort, encompassing over 6545 samples. Red tones indicate fractions that increase with increasing values of the epidemiological factors, blue tones indicate decreases. P-values were derived from a multivariate linear regression including all phenotypic factors as shown