Table 4.

Multivariate Risk for metachronous CRC after removal of polyp(s) at baseline colonoscopy adjusted for presence of polyps.

	Number of individuals	Number of CRC	Cases per 1000 person-years of follow-up	Univariate HR (95% CI)	p-value	Multivariate HR (95% CI)a	p-value
HP <10 mm	30,580	72	0.74	1.281 (0.998–1.644)	0.052
SSL <10 mm, no dysplasia	10,521	19	0.63	1.098 (0.694–1.736)	0.690
SSL low-risk 1–4	10,393	19	0.64	1.113 (0.704–1.760)	0.648
SSL low-risk ≥5	128	0		NA	NA
Low-risk adenoma 1–4	93,715	178	0.59	0.980 (0.817–1.177)	0.831
Low-risk adenoma 3–4	15,439	34	0.53	1.191 (0.841–1.687)	0.325
Proximal serrated polyp	29,161	70	0.78	1.357 (1.054–1.746)	0.018	1.182 (0.906–1.542)	0.226
Proximal adenoma	86,178	223	0.79	1.559 (1.307–1.858)	<0.001	1.360 (1.130–1.637)	0.001
Tubular adenoma	145,028	307	0.64	1.133 (0.947–1.355)	0.171
Tubulovillous adenoma	54,806	152	0.76	1.286 (1.063–1.556)	0.010	1.079 (0.884–1.317)	0.456
Villous adenoma	3427	22	1.64	2.591 (1.690–3.973)	<0.001	2.069 (1.341–3.190)	0.001
High-risk polyps
Serrated polyp ≥10 mm	9829	27	0.84	1.407 (0.955–2.073)	0.085
SSL with dysplasia	2911	11	1.14	1.897 (1.043–3.447)	0.036	1.467 (0.789–2.726)	0.226
Traditional serrated adenoma	2125	11	1.48	2.424 (1.334–4.406)	0.004	2.089 (1.144–3.816)	0.017
Adenoma ≥10 mm	69,331	159	0.64	1.026 (0.850–1.238)	0.789
Adenoma with HGD	9796	53	1.45	2.420 (1.821–3.218)	<0.001	2.059 (1.529–2.771))	<0.001
≥5 low-risk adenomas	5815	20	1.11	1.906 (1.219–2.981)	0.005	1.459 (0.924–2.304)	0.105

HP: Hyperplastic polyp, SSL: Sessile serrated lesion, HGD: High-grade dysplasia.

^aAdjusted for age at baseline colonoscopy, sex, and other significant subgroups at univariate analysis.