Table 7.
Summary of all studies on chronic osteomyelitis reporting recurrence rate as available in literature.
| Study (year) | Inclusion criteria | Sample size (n) | Surgical debridement | Local antibiotics | Systemic antibiotics | Recurrence rate (%) |
|---|---|---|---|---|---|---|
| Ellur et al.4 (2020) | CHOM, age ≤ 15 years | 31 | Yes | Antibiotic loaded calcuim sulfate pellets | 5 weeks | 0 |
| Lowneberg et al.9 (2019) | All ages and aetiologies | 127 | Yes | None | 2 – 6 days | 1.6 |
| Petfield et al.11 (2019) | Posttraumatic COM tibia following wartime open fracture | 112 | Yes | None | Yes, no mention of duration | 28 |
| Masrouha et al.5 (2018) | Infected non-union | 13 | Yes | Antibiotic loaded calcuim sulfate pellets | 3 – 5 days | 0 |
| Jerzy et al.28 (2018) | All ages and aetiologies | 30 | Yes | Topically during surgery | 6 weeks | 5 |
| Pozo et al.13 (2018) | All ages and aetiologies | 116 | In 107 patients | None | 3 – 4 weeks | 22.4 |
| Jorge et al.14 (2017) | Post traumatic COM, age >12 years | 193 | Yes | None | Yes, no mention of duration | 19.8 |
| Laghmouche et al.32 (2017) | COM caused by Pseudomonas aeuroginosa | 67 | Yes | None | 3 – 13 weeks | 20.9 |
| Chadayammuri et al.12 (2017) | Posttraumatic COM | 142 | Yes | None | 6 weeks | 34.5 |
| McNally et al.26 (2016) | All ages and aetiologies | 100 | Yes | Gentamicin loaded calcuim sulfate hydroxyapatite biocomposite | 6 – 12 weeks | 4 |
| Marais et al.27 (2016) | All ages and aetiologies | 26 | 12 patients in curative, no surgery for 14 patients in palliative group | Antibiotic loaded PMMA beads in 4 patients | 6 weeks in curative group, 3 – 6 months in palliative group | 4.8 |
| Mondal et al.29 (2015) | All ages and aetiologies | 30 | Yes | PMMA beads | 2 doses | 6.7 |
| Fergeuson et al.30 (2014) | All ages and aetiologies | 195 | Yes | Antibiotic loaded calcium sulfate | 6 – 12 weeks | 9.2 |
| Baldan et al.33 (2014) | All ages and aetiologies | 71 | Yes | None | 4 weeks | 33 |
| Ikpeme et al.34 (2013) | All ages and aetiologies | 44 | Yes | Antibiotic loaded PMMA beads in 18 patients | 6 weeks | 34.1 |
| Mantero et al.10 (2011) | Age <18 years, all aetiologies | 90 | Yes | None | 6 weeks | 12.2 |
| Beckless et al.31 (2010) | CHOM, age ≤15 years | 167 | Yes | None | 6 weeks | 16 |
| Agaja et al.25 (2008) | All ages and aetiologies | 107 | Yes | None | 6 weeks | 2.8 |
| Biruk et al.6 (2007) | All ages and aetiologies | 73 | Yes | None | 4 – 6 weeks | 48 |
| Tice et al.8 (2003) | All ages and aetiologies | 454 | None | None | 2 – 6 weeks | 30.6 |
COM: chronic osteomyelitis; CHOM: chronic hematogenous osteomyelitis; PMMA: polymethyl methacrylate.