TABLE 2.
In vivo epinephrine-induced ocular reactivation in latently infected rabbitsa
| Virus or P value comparison | No. of virus-positive rabbitsb/total no. of rabbits (%) or P value | No. of virus-positive eyes/total no. of eyes (%) or P value | No. of virus-positive eye swabs/total no. of eye swabs (%) or P value |
|---|---|---|---|
| Viruses | |||
| McKrae | 4/7 (57) | 7/14 (50) | 23/98 (24) |
| dLAT371 | 7/7 (100) | 9/14 (64) | 20/98 (20) |
| dLAT2903 | 4/16 (25) | 4/32 (13) | 8/192 (4) |
| P value comparisonsc | |||
| dLAT371 vs McKrae | 0.19 | 0.70 | 0.73 |
| dLAT371 vs dLAT2903 | 0.001 | 0.0008 | <0.0001 |
| dLAT2903 vs McKrae | 0.18 | 0.01 | <0.0001 |
| Virusesc | |||
| 17syn+ | 7/11 (64) | 12/22 (55) | 48/154 (31) |
| 17ΔSty | 2/9 (22) | 2/18 (11) | 4/126 (3) |
| 17ΔSty-Res | 5/8 (63) | 10/16 (63) | 35/112 (31) |
| P value comparisons | |||
| McKrae vs 17syn+ | 1.0 | 1.0 | 0.2 |
| dLAT371 vs 17ΔSty | 0.003 | 0.003 | <0.0001 |
| dLAT2903 vs 17ΔSty | 1.0 | 1.0 | 0.77 |
| 17ΔSty-Res vs 17syn+ | 1.0 | 0.74 | 1.0 |
a
Rabbits were infected with 2 × 105 PFU of the indicated virus per eye and subjected to epinephrine iontophoresis approximately 30 days p.i., and in vivo-induced reactivation was monitored by culturing tears daily for 7 consecutive days, as described previously (7). Data presentation and statistical analyses are as described for Table 1.
b
Number of rabbits in each group that had at least one virus-positive tear culture within 7 days of induction.
c
Data reproduced from a previous publication (7).