. 2023 Jul 12;12(8):e230122. doi: 10.1530/EC-23-0122
This work is licensed under a Table 2.
COVID-19 infection status and health during the preceding 12 months.
| Addison’s disease (n = 82) | Congenital adrenal hyperplasia (n = 80) | P-value | |
|---|---|---|---|
| COVID-19 diagnosed or suspected, n (%)a | 15 (18.3)b | 32 (40.0) | 0.003 |
| COVID-19 diagnosed | 5 | 9 | |
| Severe disease | 2 | 2 | |
| COVID-19 suspected but subject not tested | 10 | 23 | |
| Had sick days in the past 12 months, n (%) | 51 (62.2)c | 50 (62.5)c | >0.999 |
| Malaise/fatigue | 17 | 15 | |
| COVID-19 (confirmed or suspected) | 10 | 15 | |
| Gastroenteritis | 8 | 8 | |
| Urinary tract infection | 4 | 3 | |
| Upper respiratory tract infection | 3 | 10 | |
| Lower respiratory tract infection | 3 | 1 | |
| Skin infection | 3 | – | |
| Tooth abscess | 3 | – | |
| Flu-like symptoms | 3 | 5 | |
| Psychological stress/bereavement | 3 | 2 | |
| Physical trauma | 2 | 1 | |
| COVID-19 vaccine/flu jab | 2 | 2 | |
| Ear infection | 2 | 1 | |
| Irritable bowel syndrome | – | 3 | |
| Physical activity | – | 2 | |
| Headache/migraine | – | 2 | |
| Cough | – | 1 | |
| Non-specific symptoms | – | 1 | |
| Had an adrenal crisis in the past 12 months, n (%) | 10 (12.2) | 8 (10.0)d | 0.804 |
| COVID-19 (confirmed or suspected) | 2 | 2 | |
| Gastroenteritis | 2 | 1 | |
| Urinary tract infection | 2 | – | |
| Dental abscess | 1 | – | |
| Flu-like symptoms | 1 | – | |
| Zoledronate infusion | 1 | – | |
| Unknown trigger | 1 | 5 | |
| Physical activity | / | 1 | |
| Had hospital admissions in the past 12 months, n (%)e | 8 (9.8) | 14 (17.5)d | 0.174 |
| Physical trauma/traumatic fracture | 2 | 2 | |
| Lower respiratory tract infection | – | 3 | |
| Gastroenteritis | 1 | 1 | |
| Surgery (planned or emergency) | 1 | 2 | |
| Transient ischaemic attack | – | 2 | |
| Urinary tract infection | – | 2 | |
| Chest pain | 1 | 1 | |
| Hypertension, tachycardia | 1 | – | |
| Miscarriage | 1 | – | |
| Delivery | – | 1 | |
| Diabetic ketoacidosis | – | 1 | |
| Cellulitis | 1 | – | |
| Migraine | – | 1 |
aSignificant figure; bof the three patients with autoimmune polyendocrine syndrome type 1, one developed mild symptoms of COVID-19 and did not require hospital admission; csome patients had multiple sick days; done patient had two adrenal crises and three hospital admissions; eexcluding hospital admissions for adrenal crisis and/or severe COVID-19.