Table 1.

Results from the general linear model with repetition of assessment (time) and comparison between groups as well as interaction effect for time and group. Data are presented as mean (s.d.), and P-values.

	Number of, n		GD, mean (s.d.)		Controls, mean (s.d.)		P-values
	GD	CON	HP	15 months	0 month	15 months	Time	Interaction	Group
MFS	53	39	17.5 (6.3)	9.5 (6.4)	5.6 (5.5)	4.3 (3.5)	<0.001	<0.001a	<0.001
Depression	53	38	7.5 (4.1)	3.9 (4.2)	1.9 (1.9)	2.0 (2.0)	<0.001	<0.001a	<0.001
Anxiety	53	38	8.3 (4.2)	5.0 (3.9)	3.0 (2.5)	3.0 (2.4)	<0.001	<0.001a	<0.001
TMT A	50	38	28.3 (12.0)	23.8 (8.4)	27.6 (8.1)	25.3 (6.8)	<0.001	0.218	0.839
TMT B	50	38	67.8 (25.1)	62.0 (27.4)	63.6 (24.0)	58.9 (21.0)	0.014	0.778	0.457
TMT C	49	38	63.0 (22.0)	58.7 (24.3)	58.2 (21.5)	58.1 (15.8)	0.194	0.215	0.537
TMT D	49	38	110.7 (36.7)	100.8 (41.1)	111.5 (37.7)	106.5 (42.5)	0.041	0.504	0.676
DSC	50	38	78.4 (13.4)	81.5 (16.1)	80.9 (12.9)	84.1 (11.6)	<0.001	0.672	0.326
Digit span	50	38	15.6 (3.9)	15.0 (3.5)	14.9 (3.6)	16.0 (3.5)	0.340	0.005a	0.770
Digit span forward	50	38	9.2 (2.0)	8.9 (1.8)	8.6 (2.3)	9.5 (1.9)	0.125	0.008	0.957
Digit span backward	50	38	6.3 (2.0)	6.3 (1.7)	6.6 (3.2)	6.7 (2.2)	0.954	0.954	0.420
FAS	50	38	42.6 (11.4)	45.5 (11.2)	42.1 (11.1)	45.2 (11.5)	0.954	0.954	0.420
RS Words/s	49	38	3.11 (0.87)	3.08 (0.75)	3.10 (0.82)	3.43 (0.76)	0.007	<0.001a	0.355

^aIndicates that significance remains after the Bonferroni–Holm correction.

CON, controls; DSC, digit symbol coding; FAS, word fluency test; GD, Graves’ disease; HP, hyperthyroid phase; m, months; MFS, Mental Fatigue Scale; RS, reading speed; TMT, trail making test.