Table 1.
Investigations on presentation.
| Investigation | Result | Normal range |
|---|---|---|
| Blood profile | ||
| Hemoglobin (g/dl) | 9.1 | 11–13.7 |
| Hematocrit (%) | 29.7 | 34–44 |
| Total WBC count (cells/µl) | 7,180 | 4,500–13,500 |
| Differential WBC count (%) | ||
| Neutrophil/band Lymphocyte Eosinophil Basophil Monocyte | 8.8 44.2 0.9 1.8 44.2 | 55–70 20–40 1–4 0.5–1 2–8 |
| Absolute neutrophil count (cells/µl) | 630 | 1,800–8,000 |
| Platelet count (x109 cells/L) | 128 | 150–450 |
| PT (sec) | 18.1 | 12.1–14.6 |
| PTT (sec) | 31.9 | 25.0–37.0 |
| INR | 1.45 | 0.92–1.14 |
| Fibrinogen (mg/dl) | 398 | 200–400 |
| Functional antithrombin (%) | 71 | 80–120 |
| ESR (mm/h) | 23 | 0–10 |
| Urine analysis | ||
| Glucose | Normal | |
| Blood | Negative | |
| Protein | Negative | |
| Ketone | Negative | |
| Bilirubin | Negative | |
| Liver function tests | ||
| Total bilirubin (mg/dl) | 0.2 | 0.1–1.2 |
| Direct bilirubin (mg/dl) | <0.2 | <0.3 |
| Aspartate transaminase (U/L) | 29 | 10–40 |
| Alanine transaminase (U/L) | 10 | 10–40 |
| Alkaline phosphatase (U/L) | 225 | 130–260 |
| Renal function tests | ||
| Creatinine (mg/dl) | 0.23 | 0.44–0.65 |
| BUN (mg/dl) | 8 | 5–18 |
| Inflammatory markers | ||
| C-reactive protein (mg/dl) | 4.51 | <0.9 |
| Microbiology/virology | ||
| Blood cultures | No growth | |
| MRSA surveillance cultures | Negative | |
| Respiratory pathogen testsa | Negative | |
| Coagulation profile from 2018b | ||
| Platelets (x103 cells/µl) | 108 | 223–461 |
| PT (sec) | 15.4 | 12.1–14.6 |
| INR | 1.19 | |
| PTT (sec) | 37.5 | 25.0–37.0 |
| Thrombin time (sec) | 15.7 | 14.4–18.0 |
| Fibrinogen (mg/dl) | 267 | 200–400 |
| Factor II activity (%) | 50 | 50–150 |
| Factor V activity (%) | 77 | 50–150 |
| Factor VII activity (%) | 66 | 50–150 |
| Factor XII activity (%) | 98 | 69–143 |
| PTT inhibitor screen | Negative | |
| PT inhibitor screen | Negative | |
| Lupus anticoagulant screen | Negative | |
| vWF Risto Cofactor (%) | 63 | 50–150 |
| vWF Antigen (%) | 83 | 50–160 |
| vWF VIII (%) | 79 | 70–170 |
WBC, white blood cells; PT, prothrombin time; PTT, partial thromboplastin time; INR, international normalized ratio; ESR, erythrocyte sedimentation rate; BUN, blood urea nitrogen; vWF, von Willebrand Factor.
Values outside the normal range are in bold.
a
Negative respiratory pathogen PCR tests for adenovirus, SARS-CoV-2, influenza A, influenza B, human metapneumovirus, parainfluenza 1, parainfluenza 2, parainfluenza 3, parainfluenza 4, respiratory syncytial virus, and rhinovirus.
b
After the second bleeding event.