Table 4.
Growth from birth to adult height in the ITT study subgroups; expressed in SDS versus the Turner reference (5).
| Group | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| GH start 3- <9 | GH start 9- | |||||||||
| Variables | Dose 33 µg | Dose 67 µg | p-value | Difference between groups Mean (95% CI) | Effect Size |
Dose 33 µg | Dose 67 µg | p-value | Difference between groups Mean (95% CI) | Effect Size |
| n=33 | n=46 | n=34 | n=19 | |||||||
| At birth | ||||||||||
| Height SDS | −0.58 (1.08) −0.24 (−3.04; 0.96) n=33 |
−0.21 (0.95) −0.24 (−2.24; 1.76) n=46 |
0.12 | −0.365 (−0.824; 0.089) |
0.364 | −0.01 (0.86) 0.16 (−2.24; 1.56) n=34 |
−0.24 (1.11) −0.16 (−2.24; 0.96) n=18 |
0.41 | 0.235 (−0.333; 0.785) |
0.248 |
| At GH start | ||||||||||
| Height SDS | −0.24 (0.88) −0.30 (−1.55; 1.49) n=33 |
−0.26 (0.86) −0.25 (−3.15; 1.45) n=46 |
0.94 | 0.015 (−0.378; 0.407) |
0.017 | 0.21 (0.96) 0.14 (−1.81; 2.02) n=34 |
0.13 (0.67) −0.01 (−0.95; 1.93) n=19 |
0.78 | 0.071 (−0.425; 0.573) |
0.082 |
| + 1 year all prepubertal | ||||||||||
| HeightSDS | 0.37 (0.80) 0.32 (−0.98; 2.16) n=32 |
0.81 (0.86) 0.89 (−1.85; 2.74) n=46 |
0.026 | −0.441 (−0.829; −0.056) |
0.528 | 0.82 (0.88) 0.77 (−1.06; 2.61) n=27 |
1.43 (0.70) 1.43 (0.39; 3.05) n=19 |
0.016 | −0.605 (−1.084; −0.121) |
0.748 |
| At puberty start | ||||||||||
| Height SDS | 2.30 (0.97) 2.33 (0.17; 3.79) n=33 |
3.05 (1.07) 3.1 (−0.1; 4.92) n=46 |
0.0016 | −0.753 (−1.219; −0.282) |
0.730 | 1.90 (0.75) 1.88 (−0.02; 3.64) n=34 |
2.64 (0.82) 2.86 (1.07; 3.83) n=19 |
0.0018 | −0.742 (−1.196; −0.292) |
0.952 |
| At adult height | ||||||||||
| Height SDS | 1.85 (1.01) 1.83 (−0.07; 3.62) n=33 |
2.81 (1.01) 2.9 (0.77; 4.86) n=46 |
<.0001 | −0.962 (−1.419; −0.503) |
0.952 | 2.04 (0.80) 2.2 (−0.45; 3.74) n=34 |
2.87 (0.50) 2.97 (1.78; 3.85) n=19 |
0.0002 | −0.822 (−1.234; −0.427) |
1.16 |
| Height gain | ||||||||||
|
Gain in heightSDS
GH start—Puberty onset |
2.54 (0.69) 2.42 (1.54; 4.48) n=33 |
3.31 (0.78) 3.34 (1.74; 5.3) n=46 |
<.0001 | −0.767 (−1.105; −0.429) |
1.03 | 1.70 (1.08) 1.78 (0; 4.06) n=34 |
2.51 (0.82) 2.64 (1.08; 3.69) n=19 |
0.0066 | −0.812 (−1.381; −0.233) |
0.815 |
|
Gain in heightSDS
Puberty onset—adult height |
−0.45 (0.28) −0.43 (−1.20; −0.01) n=33 |
−0.24 (0.50) −0.27 (−1.18; 0.92) n=46 |
0.032 | −0.209 (−0.401; −0.020) |
0.499 | 0.14 (0.49) 0.04 (−0.59; 1.72) n=34 |
0.22 (0.66) 0.16 (−0.85; 2.17) n=19 |
0.61 | −0.080 (−0.397; 0.246) |
0.143 |
|
Gain in heightSDS
GH start—adult height |
2.09 (0.72) 2.07 (0.69; 3.44) n=33 |
3.07 (0.76) 3.01 (1.47; 5.08) n=46 |
<.0001 | −0.977 (−1.321; −0.633) |
1.31 | 1.84 (1.03) 1.99 (−0.07; 3.99) n=34 |
2.73 (0.62) 2.91 (1.41; 3.63) n=19 |
0.0010 | −0.892 (−1.416; −0.372) |
0.983 |
For continuous variables, Mean(SD)/Median (Min; Max)/n= is presented.
For comparison between groups, the Fisher’s non-parametric permutation test was used for continuous variables.
The confidence interval for the mean difference between groups is based on Fisher’s non-parametric permutation test.
Effect size is absolute difference in mean/pooled SD.
GH, growth hormone; SDS, standard deviation score.