Table 6.
Multivariable linear regression analyses, PP population, 89 girls with Turner syndrome.
| Independent variables Beta/(95% CI)/p-value |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Before GHstart | At GHstart | 1st year | Prepub period | At Pubertal onset | ||||||||
| Karyotype | MPH (SDS) | Mother height (SDS) | Father height (SDS) | Age (years) |
Height (SDS) | Diff MPH (SDS) | Mean GHdose (µg/kg/day) | Gain in height (SDS) | Age (years) |
Height (SDS) | ||
| Dependent | R-square | |||||||||||
| Gain in Height | ||||||||||||
| Prepub gain SDS @GH |
0.4212 | 0.25 (0.11;0.40) p=0.0006 |
−0.05 (−0.09; −0.01) p=0.026 |
−0.45 (−0.64; −0.27) p<0.0001 |
0.02 (0.01;0.03) p=0.0003 |
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| Pub gain SDS @puberty |
0.4747 | 0.13 (0.10;0.16) p<0.0001 |
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| Total gain SDS @GH |
0.4131 | −1.17 (−1.91; −0.42) p=0.0024 |
0.07 (0.03;0.11) p=0.0007 |
−0.24 (−0.43; −0.04) p=0.017 |
−0.28 (−0.44; −0.11) p=0.0013 |
0.02 (0.01;0.03) p=0.0050 |
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| Total gain SDS @puberty |
0.7071 | 0.12 (0.09;0.15) p<0.0001 |
0.83 (0.71;0.95) p<0.0001 |
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| Adult height | ||||||||||||
| Adult height SDS @GH |
0.4245 | 0.28 (0.11;0.46) p=0.0019 |
0.07 (0.02;0.11) p=0.0034 |
0.45 (0.22;0.67) p=0.0002 |
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| Adult height cm @GH |
0.4245 | 1.73 (0.66;2.80) p=0.0019 |
0.41 (0.14;0.67) p=0.0034 |
2.72 (1.35;4.10) p=0.0002 |
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| Adult height SDS @puberty |
0.7726 | 0.10 (0.00;0.20) p=0.047 |
0.12 (0.09;0.14) p<0.0001 |
0.83 (0.72;0.95) p<0.0001 |
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| Adult height cm @puberty |
0.7726 | 0.60 (0.01;1.19) p=0.047 |
0.71 (0.53;0.88) p<0.0001 |
5.06 (4.37;5.75) p<0.0001 |
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| Age at Pubertal onset | ||||||||||||
| Age Puberty @GH |
0.2841 | 0.17 (0.08;0.25) p=0.0004 |
−0.05 (−0.08; −0.03) p=0.0002 |
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| Age at adult height | ||||||||||||
| Age Adult height @GH |
0.3244 | 0.18 (0.10;0.26) p<0.0001 |
−0.04 (−0.07; −0.02) p=0.0004 |
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| Age adult height @puberty |
0.4476 | 0.10 (0.02;0.18) p=0.019 |
−0.46 (−0.77; −0.14) p=0.0046 |
0.42 (0.26;0.58) p<0.0001 |
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GH, growth hormone; SDS, standard deviation score; MPH, mid-parental height; DiffMPH, difference in SDS between the height of the girl and the heights of her parents. SDS calculated versus the Swedish population for the girls (6, 57) and for the parents (58). ITT, intention to treat population; PP, per protocol population; @GHstart, model with available independent variables at GHstart; @puberty, models with available independent variables at pubertal onset.