Skip to main content
. 2023 Feb 16;109(3):323–332. doi: 10.1097/JS9.0000000000000214

Figure 3.

Figure 3

Analysis on the Cancer Genome Atlas (TCGA) panCancer Atlas (2018) rectal cancer series (READ). (A) Genes with the highest average frequency of mutations in rectal cancer patients. (B) Among these genes, two, SYNE1 and RYR2, have a higher frequency of mutation in male patients. (C) Effect of mutations of RYR2 on PD-L1 mRNA expression: PD-L1 mRNA expression is higher in male patients with mutated RYR2. (D) Effect of mutations of SYNE1 on PD-L1 and CTLA-4 mRNA expression. PD-L1 and CTLA-4 mRNA levels are higher in male patients with mutated SYNE1.