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. 2023 Feb 16;109(3):323–332. doi: 10.1097/JS9.0000000000000214

Figure 4.

Figure 4

Analysis of the IMMUNOREACT 1 and 2 cohort. (4.1A) The proportion of epithelial cells acting as antigen-presenting cells (CK+HLA ABC+) is higher males in therapy naive rectal cancer series. (4.1B) The proportion of activated CD4+Th1-cell (T-bet+) is higher in females in therapy naïve rectal cancer series. (4.1C) Overall survival tends to be better in females in therapy naive rectal cancer series. (4.2A) The proportion of epithelial cells acting as antigen-presenting cells (CK+CD86+) is higher in female patients who had neoadjuvant therapy. (4.2B) The proportion of activated CD8+T cells (CD8+CD28+) is higher in female patients who had neoadjuvant therapy. (4.2C) Overall survival tends to be better in females patients who had neoadjuvant therapy.