Table 1.
Sociodemographic and clinical characteristics of two cohorts of 1-year survivors after surgery for esophageal cancer.
| Derivation cohort | Validation cohort | ||
|---|---|---|---|
| Characteristics | N (%) | N (%) | P value* |
| Total | 1027 (100) | 558 (100) | |
| Age [median (interquartile range)] | 65.1 (58.2–71.6) | 66.7 (59.8–71.7) | 0.008 |
| Sex | 0.010 | ||
| Men | 758 (73.8) | 444 (79.6) | |
| Women | 269 (26.2) | 114 (20.4) | |
| Education (years) | <0.001 | ||
| ≤9 | 491 (47.8) | 180 (32.6) | |
| 10–12 | 383 (27.3) | 251 (45.5) | |
| >12 | 153 (14.9) | 121 (21.9) | |
| Charlson comorbidity index | <0.001 | ||
| 0 | 575 (56.0) | 220 (39.4) | |
| 1 | 436 (29.3) | 196 (35.1) | |
| ≥2 | 151 (14.7) | 142 (24.5) | |
| Tumor histology | <0.001 | ||
| Adenocarcinoma | 494 (48.1) | 452 (81.0) | |
| Squamous cell carcinoma | 533 (51.9) | 106 (19.0) | |
| Chemo(radio)therapy | 341 (33.2) | 387 (69.4) | <0.001 |
| Pathological tumor stage | <0.001 | ||
| 0–I | 331 (32.2) | 235 (42.7) | |
| II | 399 (38.9) | 87 (15.8) | |
| III | 254 (24.7) | 169 (30.7) | |
| IV | 43 (4.2) | 59 (10.7) | |
| Resection margin status | <0.001 | ||
| Radical (R0) | 933 (90.9) | 455 (82.7) | |
| Nonradical (R1 or R2) | 94 (9.2) | 95 (17.3) | |
| Reoperation within 30 days | 86 (8.4) | 28 (5.0) | 0.014 |
| Five-year all-cause mortality | 588 (57.2) | 268 (48.0) | <0.001 |
| Five-year disease-specific mortality | 516 (50.2) | 234 (41.9) | 0.002 |
*
Pearson’s χ 2 for categorical variables; quantile regression for continuous variables.