Total dextran accumulation in major organ and tumor tissues. Dextran was administered 24 hours after a 1x PBS, Liposome, or Lipoplex pretreatment injection in Balb/c female mice. Accumulation was measured 24 hours after dextran injection. X-axis represents the pretreatment that the mice received. A t-test with Welch’s correction was used to determine if Liposome/Lipoplex pretreatment showed statistically significant differences in accumulation when compared to PBS pretreatment. Statistically significant differences are represented with asterisks (* = p ≤ 0.05, ** = p ≤ 0.01, *** = p ≤ 0.001, **** = p ≤ 0.0001).