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C-PC ameliorates the senescence of MSCs through ZDHHC5 mediated autophagy via PI3K/AKT/mTOR pathway. Oxidative stress induced senescence of MSCs and increased the level of ZDHHC5 in vitro. ZDHHC5 activated PI3K/AKT/mTOR signaling and inhibited autophagy which finally promoted MSCs senescence. C-PC downregulated and reversed all the roles of ZDHHC5 on MSCs senescence.
