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Model of the PP2A holoenzyme. The rod-shaped A subunit consists of 15 repeats. Each repeat is composed of two α helices connected by an intrarepeat loop. Adjacent repeats are connected by interrepeat loops. Binding regions for B and C subunits, as well as for T antigens, are indicated by bars. Loops involved in binding are solid; loops not involved in binding are open. (Reprinted from reference 15, with permission.)
