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Comparison of PFS (A) and OS (B) in patients with PTEN 2-hit, PTEN 1-hit, and PTEN retain. Patients with PTEN homozygous deletion or PTEN mutation + loss were classified as PTEN 2-hit. Patients with either PTEN heterozygous deletion or PTEN mutation were classified as PTEN 1-hit. Patients with wild-type PTEN were classified as PTEN retain. PFS, progression-free survival; OS, overall survival.
