Table 3.
Comparison of the transplant recipients with and without IgG positivity following RT-PCR-confirmed COVID-19.
| IgG-positive (n = 32) | IgG-negative (n = 14) | p | |
|---|---|---|---|
| Age (years) | 47.5 ± 11.1 | 42.2 ± 13.8 | 0.172 |
| Male, n (%) | 23 (71.9) | 9 (64.3) | 0.427 |
| Etiology of CKD | |||
| Diabetes mellitus, n (%) | 4 (12.5) | 1 (7.1) | 0.364 |
| Glomerulonephritis, n (%) | 7 (21.9) | 1 (7.1) | |
| Others, n (%) | 21 (65.6) | 12 (85.7) | |
| Living donor, n (%) | 24 (75.0) | 11 (84.6) | 0.392 |
| Transplantation duration (months) | 108.9 ± 61.9 | 88.0 ± 78.8 | 0.337 |
| Comorbidities | |||
| Diabetes, n (%) | 10 (31.3) | 3 (21.4) | 0.381 |
| Hypertension, n (%) | 22 (68.8) | 9 (64.3) | 0.511 |
| Coronary artery disease, n (%) | 7 (21.9) | 5 (35.7) | 0.264 |
| Chronic obstructive pulmonary disease, n (%) | 2 (6.3) | 1 (7.1) | 0.673 |
| BMI (kg/m2) | 27.6 ± 4.3 | 26.9 ± 5.1 | 0.529 |
| Serum creatinine (mg/dL) | 1.33 (1.03–1.48) | 1.15 (0.87–1.83) | 0.867 |
| e-GFR* (ml/min/1.73 m2) | 63.5 ± 19.0 | 68.3 ± 33.6 | 0.537 |
| Disease severity index | |||
| Asymptomatic - moderate, n (%) | 21 (66.0) | 12 (85.0) | 0.286 |
| Severe - critical, n (%) | 11 (34.0) | 2 (15.0) | |
| Days following RT-PCR test | 37.5 (20.5–57.8) | 82.5 (52.3–105.0) | 0.001 |
| Lowest white blood cell count, (/mm3) | 4925.7 ± 1748.0 | 4596.8 ± 1667.2 | 0.582 |
| Lowest lymphocytes count, (/mm3) | 791.0 ± 603.0 | 665.4 ± 314.7 | 0.875 |
| Peak CRP, (mg/dL) | 75.8 ± 66.5 | 74.7 ± 58.0 | 0.813 |
| Peak ferritin, (ng/mL) | 625.0 (249.5–1468.3) | 670.1 (236.0–1245.0) | 0.839 |
| Fibrinogen, (mg/dL) | 447.8 (4.98–649.8) | 329.1 (4.76–515.5) | 0.439 |
| Peak D-dimer, (μg/mL) | 1.03 (0.36–2.94) | 0.91 (0.66–2.78) | 0.868 |
| Peak procalcitonin, (ng/mL) | 1.72 (0.92–127.0) | 92.5 (1.13–191.3) | 0.146 |
| Peak uric acid, (mg/dL) | 8.1 ± 2.1 | 7.7 ± 2.3 | 0.622 |
| Stopping MPA, n (%) | 17 (53.1) | 7 (50.0) | 0.549 |
| Stopping CNI, n (%) | 3 (9.4) | 0 (0.0) | NA |
| Stopping MPA or CNI, n (%) | 18 (56.3) | 7 (50.0) | 0.471 |
CKD: chronic kidney disease, BMI: body mass index, RT-PCR: reverse transcriptase-polymerase chain reaction, MPA: mycophenolic acid derivatives, CNI: calcineurin inhibitor.
*
Calculated using the CKD-EPI formula.
Values are presented as mean ± SD or as median and IQR.